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Study identifier: NCT05464030 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)

Condition: Colorectal Cancer  ·  Sponsor: EMD Serono Research & Development Institute, Inc.

PhasePhase 1
Planned participants200
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this first in-human study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary clinical activity of M9140 in advanced solid tumors. This study contains 2 parts: Dose escalation (Part 1) and dose expansion (Part 2) Study details include: * Study Duration per participant: Approximately 4 months for Part 1 and 8 months for Part 2 * M9140 is not available through an expanded access program

This description comes directly from the study's public registry record.

Talk to the study team

US Medical Information  ·  888-275-7376  ·  eMediUSA@emdserono.com

Communication Center  ·  +49 6151 72 5200  ·  service@emdgroup.com

Always discuss trial participation with your own doctor first.

Locations (35)

California Cancer Associates for Research & Excellence, Inc.Encinitas, California, United StatesCompleted
California Cancer Associates for Research & Excellence, Inc.Fresno, California, United StatesCompleted
Rhode Island HospitalProvidence, Rhode Island, United StatesRecruiting
Mary Crowley Cancer ResearchDallas, Texas, United StatesRecruiting
MD Anderson Cancer Center - OncologyHouston, Texas, United StatesRecruiting
NEXT OncologySan Antonio, Texas, United StatesRecruiting
The Ottawa Hospital Cancer CentreOttawa, CanadaRecruiting
University Health Network - Princess Margaret Cancer CentreToronto, CanadaRecruiting
National Cancer Center Hospital - Dept of GastroenterologyChūōku, JapanRecruiting
National Cancer Center Hospital EastKashiwa-shi, JapanRecruiting
Saitama Cancer CenterKitaadachi-gun, JapanRecruiting
Cancer Institute Hospital of JFCRKōtoku, JapanRecruiting

+ 23 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05464030