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Study identifier: NCT05463848 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Surgical Pembro +/- Olaparib w TMZ for rGBM

Condition: Glioblastoma · Recurrent Glioblastoma  ·  Sponsor: L. Nicolas Gonzalez Castro, MD, PhD

PhasePhase 2
Planned participants78
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This research study is studying a combination therapy as a possible treatment for recurrent glioblastoma (GBM), a brain tumor that is growing or progressing despite earlier treatment. The names of the study interventions involved in this study are/is: * Pembrolizumab * Olaparib * Temozolomide (Temodar)

This description comes directly from the study's public registry record.

Talk to the study team

Luis N Gonzalez Castro, MD  ·  617-732-7432  ·  lgonzalez-castro@partners.org

Christine J McCluskey  ·  (617) 632-5394  ·  christine_sceppa@dfci.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (4)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05463848