Condition: Ulcerative Colitis · Inflammatory Bowel Diseases · Sponsor: Central Hospital, Nancy, France
UC is a chronic, idiopathic form of intestinal inflammatory disease (IBD) that affects the colon, most commonly afflicting adults aged 30-40 years and resulting in disability and lower quality of life (1). It is characterized by relapsing and remitting mucosal inflammation, starting in the rectum and extending to proximal segments of the colon. Although biologic therapies have provided clinical benefits to patients, these goals are still poorly met, due to the limited knowledge of the underlying mechanisms of immunopathology and the lack of predictive biomarkers that would allow proper patient stratification. The hypothesis of this study is that by identifying new biomarkers in blood, stool and tissue that (i) predict response (or non-response) to therapy prior to the start of treatment and (ii) predict response to therapy in the early phase of treatment will allow to find the right treatment for the right patient (personalized medicine).
This description comes directly from the study's public registry record.
Laurent MD Peyrin-Biroulet, PhD · 0383153661 · peyrinbiroulet@gmail.com
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| Central Hospital | Nancy, Lorraine, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05456893