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Study identifier: NCT05452941 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Learn About How 20-Valent Pneumococcal Conjugate Vaccine Works in a Real-world Setting

Condition: Pneumonia  ·  Sponsor: Pfizer

PhaseN/A
Planned participants12500
Who can joinAll sexes, 65 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to learn about how well the 20-valent pneumococcal conjugate vaccine (20vPnC) works against radiologically-confirmed community-acquired pneumonia (RAD+CAP) due to the 7 new serotypes (types of a bacteria called Streptococcus pneumoniae that cause pneumonia) included in 20vPnC vaccine. This study is seeking participants who: * are male or female ≥65 years of age. * are hospitalized with physician suspicion of community acquired pneumonia (CAP). * have pneumonia confirmed with imaging like a chest x-ray Participants will be asked to provide demographic and medical history information, and to provide a urine sample that will be used to test for pneumonia caused by specific strains of a bacteria called Streptococcus pneumoniae. We will compare the proportion of participants who have pneumonia caused by specific strains of the bacteria Streptococcus pneumoniae and were previously vaccinated with 20vPnC with the proportion of participants who have pneumonia caused by something other than vaccine type Streptococcus pneumoniae and have been vaccinated with 20vPnC. Participants will actively take part in the study for about 1-2 days. Information on participant's illness and hospitalization details will be collected through day 30 of their hospitalization through medical chart review.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (54)

El Centro Regional Medical CenterEl Centro, California, United StatesRecruiting
Kaiser Permanente Fontana Medical CenterFontana, California, United StatesRecruiting
Kaiser Permanente West Los Angeles Medical CenterLos Angeles, California, United StatesRecruiting
Kaiser Permanente Vaccine Study CenterOakland, California, United StatesRecruiting
Kaiser Permanente Oakland Medical CenterOakland, California, United StatesRecruiting
Kaiser Permanente Ontario Medical CenterOntario, California, United StatesRecruiting
Southern California Permanente Medical Group (SCPMG)Pasadena, California, United StatesRecruiting
Kaiser Permanente Riverside Medical CenterRiverside, California, United StatesRecruiting
Kaiser Permanente Roseville Medical CenterRoseville, California, United StatesRecruiting
Kaiser Permanente South Sacramento Medical CenterSacramento, California, United StatesRecruiting
Kaiser Permanente Sacramento Medical CenterSacramento, California, United StatesRecruiting
Kaiser Permanente Zion Medical CenterSan Diego, California, United StatesRecruiting

+ 42 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05452941