Condition: Pancreatic Fluid Collection · Walled-off Necrosis · Pancreatitis, Acute Necrotizing · Sponsor: Tokyo University
Walled-off necrosis (WON) is a pancreatic fluid collection, which contains necrotic tissue after four weeks of the onset of acute pancreatitis. Interventions are required to manage patients with infected WON, for which endoscopic ultrasonography (EUS)-guided drainage has become a first-line treatment modality. For patients who are refractory to EUS-guided drainage, the step-up treatment including endoscopic necrosectomy (EN) and/or additional drainage is considered to subside the infection. Recent evidence suggests that EN immediately after EUS-guided drainage may shorten treatment duration without increasing adverse events. In this randomized trial, the investigators will compare treatment duration between EN immediately after EUS-guided drainage versus the step-up approach in patients with symptomatic WON.
This description comes directly from the study's public registry record.
Yousuke Nakai · +81-3-3815-5411 · ynakai-tky@umin.ac.jp
Tomotaka Saito · +81-3-3815-5411 · tomsaito-gi@umin.ac.jp
Always discuss trial participation with your own doctor first.
| Department of Gastroenterology, The University of Tokyo Hospital | Bunkyō-Ku, Tokyo, Japan | Not Yet Recruiting |
| Department of Gastroenterology, Graduate School of Medicine, Juntendo University | Bunkyō-Ku, Tokyo, Japan | Recruiting |
| Department of Gastroenterology, Aichi Medical University | Aichi, Japan | Recruiting |
| Department of Gastroenterology, Graduate School of Medicine, Chiba University | Chiba, Japan | Recruiting |
| Department of Gastroenterology, Gifu Municipal Hospital | Gifu, Japan | Recruiting |
| Department of Gastroenterology, Gifu Prefectural General Medical Center | Gifu, Japan | Recruiting |
| First Department of Internal Medicine, Gifu University Hospital | Gifu, Japan | Not Yet Recruiting |
| Division of Gastroenterology and Hepatobiliary and Pancreatic Diseases, Department of Internal Medicine, Hyogo Medical University | Hyōgo, Japan | Recruiting |
| Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University | Kagawa, Japan | Recruiting |
| Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences | Kagoshima, Japan | Recruiting |
| Department of Gastroenterology, Kameda Medical Center | Kamogawa, Japan | Recruiting |
| Department of Gastroenterological Endoscopy, Kanazawa Medical University | Kanazawa, Japan | Not Yet Recruiting |
+ 9 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05451901