Condition: Trauma · Haemorrhagic Shock · Coagulopathy · Sponsor: Australian and New Zealand Intensive Care Research Centre
Annually over 7000 Australians are treated for severe trauma. Haemorrhage secondary to severe trauma is a major cause of potentially preventable death and poor outcomes in Australian adults. Severe trauma may trigger changes in blood clotting mechanisms and factor levels leading to inhibition of clot formation and reduced clot strength. This results in the inability of the severely injured trauma patient to form adequate clots to help stop bleeding. There is good evidence to suggest the loss of clotting factors during haemorrhage is associated with worse outcomes and it is thought the early replacement of these factors may reduce bleeding and improve patient outcomes. Fibrinogen is a key clotting factor that helps bind clots together and early fibrinogen replacement may improve outcomes. Currently fibrinogen is replaced using cryoprecipitate, a blood product made from blood donated by healthy donors which is a precious resource. It can take a significant amount of time to administer as it is frozen and stored in the blood bank. Timely administration of cryoprecipitate is difficult as it requires thawing prior to transfusion. The large doses of cryoprecipitate used in traumatic haemorrhage can put strain on local blood banks in supplying requested units in a timely manner. Additionally, the widely dispersed population of Australia introduces logistic challenges to the maintenance of adequate cryoprecipitate stocks to individual hospital blood banks, especially in remote regio…
This description comes directly from the study's public registry record.
James Winearls, MBBS · +61399030379 · james.winearls@health.qld.gov.au
Bridget Ady · +61399056643 · bridget.ady@monash.edu
Always discuss trial participation with your own doctor first.
| John Hunter Hospital | Newcastle, New South Wales, Australia | Recruiting |
| St Vincent's Hospital | Sydney, New South Wales, Australia | Recruiting |
| Royal Prince Alfred Hospital | Sydney, New South Wales, Australia | Recruiting |
| Royal North Shore Hospital | Sydney, New South Wales, Australia | Recruiting |
| Westmead Hospital | Sydney, New South Wales, Australia | Recruiting |
| Liverpool Hospital | Sydney, New South Wales, Australia | Recruiting |
| Royal Darwin Hospital | Darwin, Northern Territory, Australia | Recruiting |
| Royal Brisbane and Women's Hospital | Brisbane, Queensland, Australia | Recruiting |
| Princess Alexandra Hospital | Brisbane, Queensland, Australia | Recruiting |
| Cairns Hospital | Cairns, Queensland, Australia | Recruiting |
| Gold Coast University Hospital | Gold Coast, Queensland, Australia | Recruiting |
| Rockhampton Hospital | Rockhampton, Queensland, Australia | Recruiting |
+ 12 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05449834