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Study identifier: NCT05448807 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children

Condition: Soft Tissue Injuries  ·  Sponsor: Cairo University

PhasePhase 3
Planned participants100
Who can joinAll sexes, 5 Years to 7 Years
Healthy volunteersYes

About this study

Local anaesthesia is considered one of the most alarming and non-comfortable dental procedures for children. This goes back to the persisting effect of the local anaesthesia after finishing dental procedures. The effect of Local anaesthesia can last from 3 to 5 hours due to the presence of vasoconstrictor. The U.S Food and Drug Administration (FDA approved the use of phentolamine mesylate (Oraverse) in May 2008 to be used as a drug in reversing the numbing effect of Local anaesthesia by decreasing the time needed to restore the normal functions of the mouth

This description comes directly from the study's public registry record.

Talk to the study team

alaa saad abourawash  ·  01144942076  ·  alaa.saad@dentistry.cu.edu.eg

passant nagy  ·  01280557107  ·  passant.nagi@dentistry.cu.edu.eg

Always discuss trial participation with your own doctor first.

Locations (1)

Cairo UniversityCairo, El Manial, EgyptRecruiting

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Source record: clinicaltrials.gov/study/NCT05448807