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Study identifier: NCT05447559 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study

Condition: Surgical Site Infection  ·  Sponsor: Monash University

PhasePhase 4
Planned participants9180
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections, health economic and microbiological impact after intraoperative only (Arm A), to 24 hours (Arm B) and, to 48 hours (Arm C) of IV cefazolin and placebo postoperative surgical antimicrobial prophylaxis in patients undergoing cardiac surgery

This description comes directly from the study's public registry record.

Talk to the study team

Paige Druce, MSc(Epi)  ·  9903 0016  ·  paige.druce@monash.edu

Sarah Astbury  ·  9076 6071  ·  sarah.astbury@monash.edu

Always discuss trial participation with your own doctor first.

Locations (27)

UT Southwestern Medical CentreDallas, Texas, United StatesNot Yet Recruiting
Westmead HospitalSydney, New South Wales, AustraliaRecruiting
St George HospitalSydney, New South Wales, AustraliaActive Not Recruiting
The Prince Charles HospitalBrisbane, Queensland, AustraliaRecruiting
Princess Alexandra HospitalBrisbane, Queensland, AustraliaRecruiting
St Andrew's War Memorial HospitalBrisbane, Queensland, AustraliaActive Not Recruiting
Royal Adelaide HospitalAdelaide, South Australia, AustraliaRecruiting
Flinders Medical CentreAdelaide, South Australia, AustraliaRecruiting
Flinders PrivateAdelaide, South Australia, AustraliaRecruiting
Royal Hobart HospitalHobart, Tasmania, AustraliaRecruiting
The Alfred HospitalMelbourne, Victoria, AustraliaRecruiting
The Royal Melbourne HospitalMelbourne, Victoria, AustraliaRecruiting

+ 15 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05447559