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Study identifier: NCT05442671 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

Condition: Pulmonary Hypertension  ·  Sponsor: Children's Hospital of Philadelphia

PhaseNA
Planned participants25
Who can joinAll sexes, 8 Years to 18 Years
Healthy volunteersNo

About this study

Children with pulmonary hypertension (PH) engage in less physical activity than their peers. This is a concern since adult data support exercise as a non-pharmacologic treatment for PH. Despite adult data, therapeutic exercise has not been widely adopted in pediatric PH. Investigators have previously demonstrated that children with PH have less skeletal muscle mass in association with worse exercise performance. Interventions to increase physical activity and skeletal muscle mass may improve exercise performance and quality of life in children with PH. This study will use wearable activity monitoring devices to promote physical activity in a 16-week pilot intervention in children and teenager with PH.

This description comes directly from the study's public registry record.

Talk to the study team

Catherine Avitabile, MD  ·  215-590-4040  ·  avitabilec@chop.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Children's Hospital of PhiladelphiaPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05442671