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Study identifier: NCT05442034 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Rh-PDGF vs EMD for Treatment of Intra-bony Defects

Condition: Intrabony Periodontal Defect  ·  Sponsor: Nova Southeastern University

PhasePhase 1/Phase 2
Planned participants36
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

Treatment of intra-bony defects is challenging and requires extensive knowledge of the etiology, anatomy, occlusion, and available biomaterials that can be used to treat this kind of defects. Patients who received scaling and root planing at the college of dental medicine due to periodontal disease, will be screened for inclusion. Only subjects who showed persistent deep probing depth associated with an intrabony defect will be included and will be randomly allocated to one of two treatment groups. One group will be treated using recombinant human platelet derived growth factor (GEM-21) (test) added to allogenic bone graft, second group will be treated using enamel matrix derivatives (EMD) (control) with allograft. Both groups will be treated using the same surgical protocol. Patients will be followed up for a period of 6 months and 12 months, before getting re-evaluated for assessing the effectiveness of the applied therapies.

This description comes directly from the study's public registry record.

Talk to the study team

Neshatafarin Manouchehri, D.D.S  ·  7342494806  ·  nm1859@mynsu.nova.edu

Theofilos Koutouzis, DDS, MS  ·  954-262-1742  ·  tkoutouzis@nova.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Nova Southeastern UniversityDavie, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05442034