Condition: Respiratory Insufficiency · Extracorporeal Membrane Oxygenation Complication · Mechanical Ventilation Pressure High · Sponsor: University Health Network, Toronto
PRACTICAL is a randomized multifactorial adaptive platform trial for acute hypoxemic respiratory failure (AHRF). This platform trial will evaluate novel interventions for patients with AHRF across a range of severity states (i.e., not intubated, intubated with lower or higher respiratory system elastance, requiring extracorporeal life support) and across a range of investigational phases (i.e., preliminary mechanistic trials, full-scale clinical trials). AHRF is a common and life-threatening clinical syndrome affecting millions globally every year. Patients with AHRF are at high risk of death and long-term morbidity. Patients who require invasive mechanical ventilation are at risk of ventilator-induced lung injury and ventilator-induced diaphragm dysfunction. New treatments and treatment strategies are needed to improve outcomes for these very ill patients. Utilizing advances in Bayesian adaptive trial design, the platform will facilitate efficient yet rigorous testing of new treatments for AHRF, with a particular focus on mechanical ventilation strategies and extracorporeal life support techniques as well as pharmacological agents and new medical devices. The platform is designed to enable evaluation of novel interventions at a variety of stages of investigation, including pilot and feasibility trials, trials focused on mechanistic surrogate endpoints for preliminary clinical evaluation, and full-scale clinical trials assessing the impact of interventions on patient-center…
This description comes directly from the study's public registry record.
Rongyu ( Cindy) Jin · 4163404800 · rongyu.jin@uhn.ca
Cathy Chau · 4167272260 · cathy.chau@uhn.ca
Always discuss trial participation with your own doctor first.
| University of Arizona | Tucson, Arizona, United States | Recruiting |
| University of California Los Angeles (UCLA) | Los Angeles, California, United States | Recruiting |
| University of San Diego (UCSD) | San Diego, California, United States | Recruiting |
| University of California San Francisco | San Francisco, California, United States | Recruiting |
| University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| University of Kentucky | Lexington, Kentucky, United States | Recruiting |
| University of Maryland Medical System | Baltimore, Maryland, United States | Recruiting |
| The Johns Hopkins Medicine | Baltimore, Maryland, United States | Recruiting |
| VA Ann Arbor Healthcare System | Ann Arbor, Michigan, United States | Not Yet Recruiting |
| University of Michigan Health | Ann Arbor, Michigan, United States | Recruiting |
| Washington University | St Louis, Missouri, United States | Recruiting |
| University of Nebraska Medical Center | Omaha, Nebraska, United States | Recruiting |
+ 77 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05440851