Condition: Rumination · Major Depressive Disorder · Anxiety · Sponsor: University of Pennsylvania
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.
This description comes directly from the study's public registry record.
Camille Blaine · 215-573-0828 · camille.blaine@pennmedicine.upenn.edu
Almaris Figueroa-Gonzalez · 215-746-6751 · almaris.figueroa-gonzalez@pennmedicine.upenn.edu
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| University of Pennsylvania | Philadelphia, Pennsylvania, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05437705