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Study identifier: NCT05437562 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Randomized Clinical Trial for Ewing Amputation in the VA

Condition: Peripheral Arterial Disease  ·  Sponsor: VA Office of Research and Development

PhaseNA
Planned participants120
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

This study follows the Pilot Investigation of Ewing Amputation for Veterans with PAD Undergoing a Below Knee Amputation. The 2 year pilot feasibility phase has concluded recruitment and enrollment. The current phase is a 5 year randomized study of Ewing Below Knee Amputation vs. Standard Below Knee Amputation. If Veterans participate, they will be randomized to either Ewing Amputation or Standard Below Knee Amputation. The scientific premise motivating this proposal is that Ewing Amputation is a promising surgical technique that may improve walking metrics in dysvascular Veterans by providing a better residual limb and improving pain and balance. In preparation of this proposal, we have formed multi-disciplinary surgical teams at each site, and we have been supported by a clinical trial planning meeting to garner the considerable expertise in rehabilitation and amputee assessment from VA and DOD experts to assist in the design of this proposal, testing the overall hypothesis that: Ewing Amputation can help Veterans walk.

This description comes directly from the study's public registry record.

Talk to the study team

Luke P Brewster, MD  ·  (404) 321-6111  ·  Luke.Brewster@va.gov

Madhur Sancheti, MS  ·  (404) 321-6111  ·  madhur.sancheti@va.gov

Always discuss trial participation with your own doctor first.

Locations (3)

Atlanta VA Medical and Rehab Center, Decatur, GADecatur, Georgia, United StatesRecruiting
Tennessee Valley Healthcare System Nashville Campus, Nashville, TNNashville, Tennessee, United StatesRecruiting
Michael E. DeBakey VA Medical Center, Houston, TXHouston, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05437562