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Study identifier: NCT05435781 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal Insufficiency

Condition: Adrenal Insufficiency · Polymyalgia Rheumatica · Giant Cell Arteritis  ·  Sponsor: Marianne Christina Klose

PhasePhase 4
Planned participants250
Who can joinAll sexes, 50 Years to no upper limit
Healthy volunteersNo

About this study

In this double-blinded randomised placebo-controlled clinical trial, the aim is to determine the effect of supplemental hydrocortisone compared with placebo during mild to moderate physical or mental stress on health related quality of life in patients with polymyalgia rheumatica (PMR)/giant cell arteritis (GCA) on ongoing low-dose prednisolone diagnosed with glucocorticoid-induced adrenal insufficiency. The main emphasis is on fatigue (primary outcome) and daily variation hereof during periods of stress.

This description comes directly from the study's public registry record.

Talk to the study team

Marianne Klose, MD, PhD  ·  +4530237532  ·  marianne.christina.klose.01@regionh.dk

Stina W. Borresen, MD, PhD  ·  +4525347551  ·  stina.borresen@regionh.dk

Always discuss trial participation with your own doctor first.

Locations (3)

Department of Endocrinology, Aarhus University HospitalAarhus, DenmarkRecruiting
Department of Medical Endocrinology, Copenhagen University Hospital, RigshospitaletCopenhagen, DenmarkRecruiting
Department of Endocrinology, Odense University HospitalOdense, DenmarkRecruiting

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Source record: clinicaltrials.gov/study/NCT05435781