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Study identifier: NCT05435300 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Does tDCS Change Synaptic Density in the Brains of Patients With Schizophrenia

Condition: Schizophrenia · Schizoaffective  ·  Sponsor: Centre for Addiction and Mental Health

PhaseN/A
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study will examine changes in synaptic density with transcranial direct current stimulation (tDCS) in the brains of patients with schizophrenia. Synaptic density levels will be measured using a novel positron emission tomography (PET) radiotracer \[18F\]SDM-8, which is currently the best-in-class method to quantify synaptic density in humans. This will be a companion study to a parent study by our group examining the effects of tDCS on treatment adherence in schizophrenia (REB #103-2018).

This description comes directly from the study's public registry record.

Talk to the study team

Philip Gerretsen, MD, PhD  ·  416-535-8501  ·  philip.gerretsen@camh.ca

Ariel Graff, MD, PhD  ·  416-535-8501  ·  ariel.graff@camh.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Centre for Addiction and Mental HealthToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05435300