Condition: Pre-Eclampsia · Pregnancy Induced Hypertension · Pregnancy Related · Sponsor: University of Oxford
Study background High blood pressure during pregnancy is a worldwide health problem that can be dangerous to mothers and commonly causes premature birth and small babies. There is also growing evidence that mothers who suffer from high blood pressure in pregnancy, and their babies, have a higher risk of high blood pressure and cardiovascular disease later in life. Previous studies have revealed detrimental changes in the structure and function of the heart and blood vessels of mothers, and their babies, who experience this common complication. These changes may explain their increased risk of later disease. The investigators have also learned through previous studies that tetrahydrobiopterin (BH4), a molecule that has a role in blood vessel health, plays an important role in stabilising blood vessel function. Lower levels of BH4 are evident in both the placenta and the umbilical cord from mothers with high blood pressure. We, therefore, want to investigate how closely BH4 levels are related to clinical features of pre-eclampsia and whether altering levels of BH4, using a nutritional supplement, improves features of the disease such as blood vessel function. To do this, the investigators need to compare the levels of BH4 between mothers with pre-eclampsia, those taking the supplement and those without pre-eclampsia. The investigators also compare how the heart and blood vessels look and function in these groups using ultrasound methods, including echocardiography and fetal so…
This description comes directly from the study's public registry record.
Annabelle Frost, MD · 01865 572833 · carefol-ht@cardiov.ox.ac.uk
Cheryl Tan, MRes · 01865 572833 · cheryl-mj.tan@cardiov.ox.ac.uk
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| Oxford University Hospitals NHS Foundation Trust | Oxford, Oxfordhsire, United Kingdom | Recruiting |
| Cardiovascular Clinical Research Facility | Oxford, Oxfordshire, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05434195