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Study identifier: NCT05434130 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Modulating Exercise Dosage to Improve Concussion Recovery

Condition: Concussion, Brain · Treatment · Aerobic Exercise  ·  Sponsor: University of Colorado, Denver

PhasePhase 2
Planned participants216
Who can joinAll sexes, 13 Years to 18 Years
Healthy volunteersNo

About this study

Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.

This description comes directly from the study's public registry record.

Talk to the study team

David R Howell, PhD  ·  7207771502  ·  ConcussionResearch@cuanschutz.edu

Kelsie Richardson, MS  ·  7207771502  ·  ConcussionResearch@cuanschutz.edu

Always discuss trial participation with your own doctor first.

Locations (3)

University of Colorado DenverAurora, Colorado, United StatesRecruiting
Boston Children's HospitalBoston, Massachusetts, United StatesRecruiting
Spaulding Rehabilitation HospitalCambridge, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05434130