Condition: Recurrent Glioblastoma, IDH-Wildtype · Recurrent MGMT-Methylated Glioblastoma · Sponsor: National Cancer Institute (NCI)
This phase I/II trial tests the safety, side effects and best dose of selinexor given in combination with the usual chemotherapy (temozolomide) and compares the effect of this combination therapy versus the usual chemotherapy alone (temozolomide) in treating patients with glioblastoma that has come back (recurrent). Selinexor is in a class of medications called selective inhibitors of nuclear export (SINE). It works by blocking a protein called CRM1, which may keep cancer cells from growing and may kill them. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid and may kill tumor cells and slow down or stop tumor growth. Giving selinexor in combination with usual chemotherapy (temozolomide) may shrink or stabilize the tumor better than the usual chemotherapy with temozolomide alone in patients with recurrent glioblastoma.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| Mayo Clinic Hospital in Arizona | Phoenix, Arizona, United States | Recruiting |
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| Keck Medicine of USC Koreatown | Los Angeles, California, United States | Suspended |
| Los Angeles General Medical Center | Los Angeles, California, United States | Suspended |
| USC / Norris Comprehensive Cancer Center | Los Angeles, California, United States | Suspended |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Recruiting |
| UCHealth University of Colorado Hospital | Aurora, Colorado, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, United States | Recruiting |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, United States | Recruiting |
| Mayo Clinic in Florida | Jacksonville, Florida, United States | Recruiting |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, United States | Recruiting |
+ 24 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05432804