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Study identifier: NCT05431270 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 mAb, Administered Alone and in Combination With a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

Condition: Non Small Cell Lung Cancer · Pancreatic Ductal Adenocarcinoma  ·  Sponsor: Phanes Therapeutics

PhasePhase 1/Phase 2
Planned participants40
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a first-in-human, Phase 1/2, open-label, study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of Mavrostobart (PT199) alone and in combination with a PD-1 inhibitor or chemotherapy.

This description comes directly from the study's public registry record.

Talk to the study team

Phanes Therapeutics  ·  858-766-0852  ·  clinical-trials@phanestx.com

Always discuss trial participation with your own doctor first.

Locations (6)

Carolina BioOncology InstituteHuntersville, North Carolina, United StatesRecruiting
Sarah Cannon Research Institute University of OklahomaOklahoma City, Oklahoma, United StatesRecruiting
SCRI Oncology PartnersNashville, Tennessee, United StatesRecruiting
The University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
Tranquility ResearchWebster, Texas, United StatesTerminated
NEXT OncologyFairfax, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05431270