Condition: Coronary Artery Disease · Heart Failure Systolic · Sponsor: Sunnybrook Health Sciences Centre
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy (STICH3C) trial is a prospective, unblinded, international multi-center randomized trial of 754 subjects enrolled in approximately 45 centers comparing revascularization by percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with multivessel/left main (LM) coronary artery disease (CAD) and reduced left ventricular ejection fraction (LVEF). The primary objective is to determine whether CABG compared to PCI is associated with a reduction in all-cause death, stroke, spontaneous myocardial infarction (MI), urgent repeat revascularization (RR), or heart failure (HF) readmission over a median follow-up of 5 years in patients with multivessel/LM CAD and ischemic left ventricular dysfunction (iLVSD). Eligible patients are considered by the local Heart Team appropriate and amenable for non-emergent revascularization by both modes of revascularization. The secondary objectives are to describe the early risks of both procedures, and a comprehensive set of patient-reported outcomes longitudinally.
This description comes directly from the study's public registry record.
Stephen Fremes, MD,MSc,FRCSC · 416-480-6100 · stephen.fremes@sunnybrook.ca
Reena Karkhanis, MBBS,DA,MSc · 416-480-6100 · reena.karkhanis@sunnybrook.ca
Always discuss trial participation with your own doctor first.
| Cedars-Sinai | Los Angeles, California, United States | Recruiting |
| Yale University | New Haven, Connecticut, United States | Recruiting |
| UofL Health, Inc | Louisville, Kentucky, United States | Recruiting |
| John Hopkins Hospital | Baltimore, Maryland, United States | Recruiting |
| Mayo Clinic | Rochester, Minnesota, United States | Withdrawn |
| University Hospitals Cleveland Medical Center | Cleveland, Ohio, United States | Recruiting |
| Medical University of Vienna | Vienna, Austria | Active Not Recruiting |
| Heart Institute, Medical School of the University of Sao Paulo_INCOR | São Paulo, Brazil | Recruiting |
| University of Calgary; Libin Cardiovascular Institute | Calgary, Alberta, Canada | Recruiting |
| Mackenzie Health Sciences Center | Edmonton, Alberta, Canada | Recruiting |
| Fraser Health; Royal Columbian Hospital | New Westminster, British Columbia, Canada | Withdrawn |
| Providence Health | Vancouver, British Columbia, Canada | Recruiting |
+ 31 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05427370