Condition: Major Depressive Disorder, Recurrent, in Remission · Sponsor: University of British Columbia
Antidepressants are widely used as first-line treatments for major depressive disorder (MDD). Clinical guidelines recommend 6-24 months of "maintenance" antidepressant treatment, after patients achieve symptom remission, to prevent relapse but many people stop antidepressants too soon relapse into another depressive episode. We will test non-medication treatments, negative ion therapy and light therapy, to see they can substitute for antidepressants to prevent relapse. This is a "feasibility" study to see if participants use study treatments properly, before doing a larger, definitive trial. In this 28-week study, 100 participants with MDD who are in remission with antidepressants will be treated with light therapy or negative ion therapy (with half of devices active and half inactive) while slowly discontinuing the antidepressant, and monitored for relapse.
This description comes directly from the study's public registry record.
Vanessa Evans, BSc · 604-822-8102 · vanessa.evans@ubc.ca
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| Djavad Mowafaghian Centre for Brain Health | Vancouver, British Columbia, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05423275