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Study identifier: NCT05417555 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Low Intensity Focused Ultrasound for Mild Cognitive Impairment and Mild Alzheimer's Disease

Condition: Mild Cognitive Impairment · Amnestic Mild Cognitive Disorder · Deep Brain Stimulation  ·  Sponsor: University of California, Los Angeles

PhaseNA
Planned participants144
Who can joinAll sexes, 50 Years to 90 Years
Healthy volunteersNo

About this study

The goal of this study is to investigate whether Low Intensity Focused Ultrasound Pulsation (LIFUP) targeting a part of the brain involved in memory will have an affect on brain activity and whether it may improve memory in people with Mild Cognitive Impairment and Mild Alzheimer's Disease. The main questions the study seeks to answer are: 1. Can LIFUP increase brain activity in the targeted area? 2. Can LIFUP improve memory in people with MCI and mild AD? 3. Can LIFUP improve connectivity of memory networks in the brain? Participants in this study will complete MRIs and memory testing, and receive Low Intensity Focused Ultrasound to a part of their brain involved in memory (the entorhinal cortex).

This description comes directly from the study's public registry record.

Talk to the study team

Natalie Rotstein  ·  ‭(310) 794-0077‬  ·  tfus@mednet.ucla.edu

Sabrina Halavi  ·  ‭(310) 794-0077‬  ·  tfus@mednet.ucla.edu

Always discuss trial participation with your own doctor first.

Locations (1)

UCLA Semel Institute for Neuroscience and BehaviorLos Angeles, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05417555