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Study identifier: NCT05414032 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC

Condition: Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC)  ·  Sponsor: University Health Network, Toronto

PhasePhase 2
Planned participants102
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a phase II, open-label study to assess the efficacy of AZD2936 in terms of molecular residual disease (MRD) clearance and treatment outcome in patients with MRD after definitive treatment for high risk locoregionally advanced head and neck squamous cell carcinoma (LA-HNSCC). MRD is defined as ctDNA detection in plasma after definitive treatment. Approximately 100 patients are expected to be enrolled.

This description comes directly from the study's public registry record.

Talk to the study team

Lillian Siu, MD  ·  416-946-4501  ·  tip@uhn.ca

Minge Xu  ·  416-946-4501  ·  Minge.Xu@uhn.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Princess Margaret Cancer CentreToronto, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT05414032