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Study identifier: NCT05410925 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction

Condition: ST Elevation Myocardial Infarction  ·  Sponsor: The First Affiliated Hospital with Nanjing Medical University

PhasePhase 4
Planned participants2260
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

As an effective treatment for acute ST-segment elevation myocardial infarction (STEMI), early reperfusion may reduce the infarct size and improve the prognosis of patients. However, it remains uncertain whether adjunctive thrombolytic therapy administered immediately prior to primary percutaneous coronary intervention (PCI) improves outcomes in patients undergoing the procedure within 120 minutes. In this investigator-initiated, prospective, multi-center, randomized, double-blind, placebo-controlled trial, subjects meeting the inclusion/exclusion criteria should be randomly assigned 1:1 to the trial group (r-SAK) or the control group (placebo). The risk of major adverse cardiovascular events within 90 days will be observed.

This description comes directly from the study's public registry record.

Talk to the study team

Chunjian Li, PHD  ·  +86 13701465229  ·  lijay@njmu.edu.cn

Chen Li, MD  ·  +86 13913886986  ·  lcicewind@outlook.com

Always discuss trial participation with your own doctor first.

Locations (61)

The First Affiliated Hospital of Nanjing Medical UniversityNanjing, Jiangsu, ChinaRecruiting
Changzhou Second People's HospitalChangzhou, ChinaRecruiting
Changzhou Wujin People's HospitalChangzhou, ChinaRecruiting
The First People's Hospital of ChangzhouChangzhou, ChinaRecruiting
Chongqing Hospital of Jiangsu Province HospitalChongqing, ChinaRecruiting
The second Affiliated Hospital of Dalian Medical UniversityDalian, ChinaRecruiting
Daqing Oilfield General HospitalDaqing, ChinaRecruiting
Dongguan People's HospitalDongguan, ChinaRecruiting
Fengcheng People's HospitalFengcheng, ChinaRecruiting
General Hospital of Southern Theatre CommandGuangzhou, ChinaRecruiting
The Second Affiliated Hospital of Hainan Medical UniversityHainan, ChinaRecruiting
The Affiliated Hospital of Hangzhou Normal UniversityHangzhou, ChinaRecruiting

+ 49 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05410925