Condition: AMD · nAMD · Wet Age-related Macular Degeneration · Sponsor: AbbVie
ABBV-RGX-314 (also known as RGX-314 and surabgene lomparvovec (sura-vec)) is being developed as a novel one-time gene therapy for the treatment of neovascular (wet) age-related macular degeneration (wet AMD). Wet AMD is characterized by loss of vision due to new, leaky blood vessel formation in the retina. Wet AMD is a significant cause of vision loss in the United States, Europe and Japan, with up to 2 million people living with wet AMD in these geographies alone. Current anti-vascular endothelial growth factor (VEGF) therapies have significantly changed the landscape for treatment of wet AMD, becoming the standard of care due to their ability to prevent progression of vision loss in the majority of patients. These therapies, however, require life-long intraocular injections, typically repeated every four to 12 weeks in frequency, to maintain efficacy. Due to the burden of treatment, patients often experience a decline in vision with reduced frequency of treatment over time. ABBV-RGX-314 is being developed as a potential one-time treatment for wet AMD.
This description comes directly from the study's public registry record.
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| Barnet Dulaney Eye Center-Phoenix /ID# 256340 | Phoenix, Arizona, United States | Recruiting |
| Retinal Research Institute /ID# 256238 | Phoenix, Arizona, United States | Recruiting |
| Retina Macula Institute of Arizona /ID# 271026 | Scottsdale, Arizona, United States | Recruiting |
| California Retina Consultants - Bakersfield /ID# 256240 | Bakersfield, California, United States | Recruiting |
| Retina Vitreous Assoc Med Grp /ID# 256246 | Beverly Hills, California, United States | Recruiting |
| Retinal Diagnostic Center /ID# 256262 | Campbell, California, United States | Recruiting |
| The Retina Partners - Encino /ID# 259660 | Encino, California, United States | Recruiting |
| Retina Consultants of Orange County /ID# 256267 | Fullerton, California, United States | Active Not Recruiting |
| Jacobs Retina Center at UCSD/ID# 256320 | La Jolla, California, United States | Active Not Recruiting |
| California Retina Consultants - Oxnard - North Ventura Road /ID# 262883 | Oxnard, California, United States | Recruiting |
| Byers Eye Institute Stanford /ID# 262853 | Palo Alto, California, United States | Recruiting |
| Retina Consultants of San Diego /ID# 256258 | Poway, California, United States | Active Not Recruiting |
+ 169 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05407636