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Study identifier: NCT05407610 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain

Condition: Knee Osteoarthritis · Persistent Postsurgical Pain · Chronic Knee Pain  ·  Sponsor: Ziekenhuis Oost-Limburg

PhaseNA
Planned participants400
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Chronic knee pain remains a disabling disease despite current treatment strategies. There is an increase in the prevalence of osteoarthritis (OA) of the knee in the general population, presently affecting approximately 450,000 individuals in Belgium. A total knee replacement is a viable alternative for severe knee OA that does not respond to conservative therapy. Unfortunately, up to 53% of patients who undergo a total knee replacement develop persistent post-surgical pain (PPSP). There is currently no effective therapy for PPSP. A radiofrequency (RF) treatment applies high frequency current on the nerve responsible for pain conduction, resulting in an interruption of the transmission of pain. This can be applied to the nerves innervating the knee joint - the superolateral, superomedial and inferomedial genicular nerves - and could be an alternative, minimally invasive treatment for patients with knee OA who fail conservative treatments and for patients with PPSP. Data from the recent literature indicates that this treatment leads to a reduction of pain intensity and could result in an improvement of knee function, of the psychological state of the individual, and finally in an increase in health-related quality of life. Furthermore, RF of the genicular nerves could help avoid or delay a total knee replacement therefore potentially contributing to cost reduction. Both cooled and conventional RF treatments are reported in the literature to improve pain. The use of water to co…

This description comes directly from the study's public registry record.

Talk to the study team

Jan Van Zundert  ·  +32 (0)89 32.52.54  ·  cogenius@zol.be

Charlotte Claes  ·  +32 (0)89 21.20.85  ·  cogenius@zol.be

Always discuss trial participation with your own doctor first.

Locations (15)

UZ AntwerpenAntwerp, BelgiumRecruiting
AZ KlinaBrasschaat, BelgiumActive Not Recruiting
ULB ErasmeBrussels, BelgiumRecruiting
UCL Saint-LucBrussels, BelgiumActive Not Recruiting
Ziekenhuis Oost-Limburg AVGenk, BelgiumRecruiting
AZ Maria MiddelaresGhent, BelgiumRecruiting
Jessa ZiekenhuisHasselt, BelgiumRecruiting
AZ GroeningeKortrijk, BelgiumActive Not Recruiting
UZ LeuvenLeuven, BelgiumRecruiting
CHR de la CitadelleLiège, BelgiumRecruiting
CHU LiègeLiège, BelgiumActive Not Recruiting
AZ DeltaRoeselare, BelgiumRecruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05407610