Condition: Colorectal Neoplasms · Sponsor: University Hospital, Akershus
In this study, the investigators will establish a reliable method and logistic pipeline for personalized drug testing ex vivo using fresh tumor samples from colorectal cancer (CRC) patients. With this, the investigators aim to develop a novel predictive biomarker of immunotherapy response, by testing combinations of chemotherapies and chimeric antigen receptor (CAR) T cells. Critically, this affects a large subgroup of patients currently not considered to benefit from such treatment. To support the hypothesis, the project will make use of cutting-edge, cell-based functional diagnostics. Individual patients' cancer cells will be screened against a panel of chemotherapies and targeted therapies including CAR T cells, to assess the optimal combination of therapies to induce immunotherapy efficacy in otherwise unresponsive CRC.
This description comes directly from the study's public registry record.
Sebastian Meltzer, M.D. Ph.D. · +4767960000 · sebastian.meltzer@medisin.uio.no
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| Akershus University Hospital | Lørenskog, Akershus, Norway | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05401318