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Study identifier: NCT05398484 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Psilocybin Therapy in Advanced Cancer

Condition: Advanced Cancer  ·  Sponsor: NYU Langone Health

PhasePhase 2/Phase 3
Planned participants200
Who can joinAll sexes, 21 Years to 100 Years
Healthy volunteersNo

About this study

The purpose of this research is to study the safety and effects of single-dose psilocybin 25mg versus an active placebo (single dose niacin 100mg) in the treatment of anxiety, depression, and existential distress (i.e., loss of meaning and hope; fear of death) in advanced cancer (i.e., stage 3 or 4). Study medications will be administered in conjunction with brief psychotherapy that is designed to treat anxiety, depression and existential distress in advanced cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Sydney Weiner, MA  ·  212-263-6283  ·  sydney.weiner@nyulangone.org

Stephen Ross, MD  ·  212-263-6289  ·  stephen.ross@nyulangone.org

Always discuss trial participation with your own doctor first.

Locations (2)

University of Colorado Anschutz Medical campus (CU AMC)Aurora, Colorado, United StatesRecruiting
NYU Langone HealthNew York, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05398484