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Study identifier: NCT05391126 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care

Condition: Colorectal Cancer · Pancreatic Cancer  ·  Sponsor: Reema A. Patel

PhaseNA
Planned participants178
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a prospective, randomized study designed to compare genotype-guided dosing to usual care in patients with pancreas cancer and colorectal cancer who are UGT1A1 intermediate metabolizers (\*1/\*28) (heterozygotes) and usual UGT metabolizers (\*1/\*1). All patients will be assessed for UGT1A1 genotype at screening and those with intermediate or usual UGT1A1 genotypes (\*1/\*28, \*1/\*1) will be randomized to genotype-guided dosing versus usual care.

This description comes directly from the study's public registry record.

Talk to the study team

Reema A Patel, MD  ·  8592186650  ·  reema.patel@uky.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of KentuckyLexington, Kentucky, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05391126