Condition: Crohn Disease · Stricture; Bowel · Intestinal Stricture · Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
This study intends to select patients with confirmed moderate-to-severe Crohn's disease (CD) and obstructive symptoms of intestinal stenosis, who have clear evidence of lumen stenosis caused by the disease itself through radiography or endoscopy. After the informed consent of the patients, comprehensive drug therapy with ustekinumab as the mainstay was performed. The basic information and medical history of the patients were collected, and the treatment process of the patients was followed up and recorded, and the drug regimen was adjusted according to the physician's experience and judgment. At different follow-up time points, blood, feces, tissue and other specimens of patients were collected according to the situation, and gastrointestinal endoscopy, imaging examination, laboratory index examination, self-assessment of subjects' symptoms, and nutritional risk screening were performed on the patients. This study evaluated the CD disease activity, obstructive symptoms, and radiographic or endoscopic remission in patients at different follow-up time points, and comprehensively evaluated the efficacy of ustekinumab in relieving stenotic CD and its related factors.
This description comes directly from the study's public registry record.
Yan Chen, MD. · +86-571-87783777 · chenyan72_72@zju.edu.cn
Jingwen Liu, MD. · +86-571-87767061 · jingwen@zju.edu.cn
Always discuss trial participation with your own doctor first.
| Department of Gastroenterology, Seventh Medical Center of PLA Army General Hospital | Beijing, Beijing Municipality, China | Recruiting |
| Department of Gastroenterology, Chongqing Renji Hospital, University of Chinese Academy of Sciences | Chongqing, Chongqing Municipality, China | Recruiting |
| Department of Gastroenterology, Sixth Affiliated Hospital, Sun Yat-Sen University | Guangzhou, Guangdong, China | Recruiting |
| Department of Gastroenterology, Huai'an First People's Hospital | Huai'an, Jiangsu, China | Recruiting |
| Department of Gastroenterology, Second Affiliated Hospital of Soochow University | Suzhou, Jiangsu, China | Recruiting |
| Department of Gastroenterology, Affiliated Hospital of Yangzhou University | Yangzhou, Jiangsu, China | Recruiting |
| Center of Inflammatory Bowel Disease, Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine | Hangzhou, Zhejiang, China | Recruiting |
| Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University | Hangzhou, Zhejiang, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05387031