Condition: Renal Transplant Rejection · Induction Therapy · Sponsor: University Hospital, Tours
Induction therapy decreases the rate of acute allograft rejection in kidney transplant recipients (KTRs) and is strongly recommended. Polyclonal lymphocyte-depleting antibodies and interleukin-2 receptor (IL2R) antagonists are therefore widely used around the world, with a leading position for rabbit anti-thymocyte globulin (rATG, Thymoglobulin®) and basiliximab (Simulect®), respectively. The actual immunological risk of the sensitized KTRs without donor specific antibodies (DSAs) is still debated. The benefit-risk equation of lymphocyte depleting antibodies (versus IL2R antagonists) is not known in sensitized KTRs without DSAs. This clinical trial will compare the efficacy and safety of basiliximab and rATG in sensitized KTR without pre-existing DSAs detected by Luminex.
This description comes directly from the study's public registry record.
Annabelle GOUMARD · 0247477263 · a.goumard@arauco.fr
Philippe GATAULT · philippe.gatault@univ-tours.fr
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| 01-TOURS | Tours, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05385432