Condition: Head Neck Cancer · Oral Cancer · Sponsor: Banaras Hindu University
Based on the recently identified mutations in HNSCCs, the major pathologic pathways implicated in the tumorigenesis of HNSCC include dysregulation of four processes: 1. cellular survival and proliferation (e.g., TP53, EGFR, MET, and PIK3CA); 2. cell-cycle control (e.g., CDKN2A and CCND1); 3. cellular differentiation (e.g., NOTCH1); and 4. Adhesion and invasion signaling (e.g., FAT1).7 TP53, EGFR, PIK3CA, CDKN2A, CCND1, and MET participate in several common signaling pathways. Alterations of these genes are most frequently seen in alcohol and tobacco-related HNSCC. However their role in prognostication and selection of therapeutics is not known
This description comes directly from the study's public registry record.
Manoj Pandey, MS, PhD · 9336363640 · manojpandey66@gmail.com
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| Banaras Hindu University | Varanasi, Uttar Pradesh, India | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05382585