Condition: Lennox Gastaut Syndrome · Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago
Lennox-Gastaut syndrome is a serious and rare form of epilepsy that begins in infancy and early childhood. Seizures and their consequences need medical attention, emergency encounters, and hospitalizations. Seizures disrupt home life for the patient and for family. Lennox-Gastaut syndrome is typically accompanied by disabilities in motor, communication, eating, and other skills needed for daily function. Lennox-Gastaut syndrome (LGS) has no cure. Although current treatments may help reduce the number of seizures, none are expected to eliminate them entirely; these treatments are palliative. The main treatments include anti-seizure medications and some surgical approaches, including the implantation of a vagus nerve stimulator (a pacemaker-like generator implanted in the chest wall and programmed by a physician to stimulate the vagus nerve in the neck) and corpus callosotomy (cutting through the band of fibers that connect the two sides of the brain). While both types of treatment (medications and surgeries) produce some benefit by reducing how often the seizures occur, both also have some risks. All medications can, in some patients, produce moderate to severe side effects. This is true of anti-seizure medications. Most patients with LGS take several anti-seizure medications at a time. Surgeries can also have associated risks and is additionally stressful for parents and family members. Currently, there is no strong evidence to support parents and physicians in deciding whic…
This description comes directly from the study's public registry record.
Sandi Lam, MD MBA · 312 227 4220 · slam@luriechildrens.org
Marc Rosenman, MD · 312 227 4220 · mrosenman@luriechildrens.org
Always discuss trial participation with your own doctor first.
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago, Illinois, United States | Recruiting |
| C.S. Mott Children's Hospital | Ann Arbor, Michigan, United States | Recruiting |
| St. Louis Children's Hospital | St Louis, Missouri, United States | Recruiting |
| Nationwide Children's | Columbus, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05374824