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Study identifier: NCT05374278 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia

Condition: Alzheimer Disease · Frontotemporal Dementia · Dementia  ·  Sponsor: David Wilson

PhasePhase 1/Phase 2
Planned participants102
Who can joinAll sexes, 40 Years to 75 Years
Healthy volunteersYes

About this study

This is a first in human study that will assess the safety and diagnostic performance of \[18F\]RP-115 (fluorine-18 labeled RP115), a positron emission tomography (PET) agent. This agent has the potential to identify the early changes that occur in the brains of patients with Alzheimer's disease (AD) and frontotemporal dementia (FTD).

This description comes directly from the study's public registry record.

Talk to the study team

David Wilson, MD, PhD  ·  415-514-6229  ·  david.m.wilson@ucsf.edu

Henry Vanbrocklin, PhD  ·  415-353-4569  ·  henry.vanbrocklin@ucsf.edu

Always discuss trial participation with your own doctor first.

Locations (1)

China Basin, UCSFSan Francisco, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05374278