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Study identifier: NCT05373758 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Randomized Clinical Trial to Evaluate Solutions for the Management of Virologic Failure on TLD in Sub-Saharan Africa

Condition: HIV Infections · AIDS · Virologic Failure  ·  Sponsor: Massachusetts General Hospital

PhaseNA
Planned participants648
Who can joinAll sexes, 15 Years to no upper limit
Healthy volunteersNo

About this study

The RESOLVE trial is an open, parallel arm, randomized clinical trial which aims to determine the optimal strategy for management of virologic failure on antiretroviral therapy (ART) with tenofovir, lamivudine, and dolutegravir (TLD) in sub-Saharan Africa. The primary outcome of interest will be viral suppression to \<50 copies/mL at 48 weeks using the FDA snapshot definition. The study will be conducted in Uganda and South Africa.

This description comes directly from the study's public registry record.

Talk to the study team

Suzanne McCluskey, MD  ·  617-726-9488  ·  smccluskey@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (3)

RK Khan Hospital ClinicDurban, South AfricaRecruiting
Mbarara City ClinicMbarara, UgandaRecruiting
Mbarara Regional Referral Hospital Immune Suppression Syndrome ClinicMbarara, UgandaRecruiting

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Source record: clinicaltrials.gov/study/NCT05373758