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Study identifier: NCT05366881 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Condition: Brain Cancer · Breast Cancer · Bladder Cancer  ·  Sponsor: Adela, Inc

PhaseN/A
Planned participants7000
Who can joinAll sexes, 40 Years to no upper limit
Healthy volunteersYes

About this study

This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, bladder, cervical, colorectal, endometrial, esophageal, gastric, head and neck, hepatobiliary, leukemia, lung, lymphoma, multiple myeloma, ovarian, pancreatic, prostate, renal, sarcoma, and thyroid. These cancers were selected based on their prevalence and mortality to maximize impact on clinical care. Additionally, the ability of the whole-genome methylome enrichment platform to detect minimal residual disease after completion of cancer treatment and to detect relapse prior to clinical presentation will be evaluated in lung cancer. This cancer was selected based on the existing clinical landscape and treatment availability.

This description comes directly from the study's public registry record.

Talk to the study team

Brian Allen, MS  ·  203-514-4155  ·  brian.allen@adelabio.com

Michelle Anderson  ·  475-766-8183  ·  michelle.anderson@adelabio.com

Always discuss trial participation with your own doctor first.

Locations (17)

City of HopeDuarte, California, United StatesRecruiting
Miami Cancer InstituteMiami, Florida, United StatesRecruiting
North Georgia Health SystemGainesville, Georgia, United StatesRecruiting
Baptist FloydNew Albany, Indiana, United StatesRecruiting
Baptist CorbinCorbin, Kentucky, United StatesRecruiting
Baptist HardinElizabethtown, Kentucky, United StatesRecruiting
Baptist LexingtonLexington, Kentucky, United StatesRecruiting
Baptist PaducahPaducah, Kentucky, United StatesWithdrawn
Allina Health Cancer InstituteMinneapolis, Minnesota, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesRecruiting
Cleveland ClinicCleveland, Ohio, United StatesRecruiting
Oregon Health Sciences UniversityPortland, Oregon, United StatesRecruiting

+ 5 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05366881