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Study identifier: NCT05366218 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Tafasitamab (MOR00208) in Pediatric Patients With Relapsed or Refractory Acute B Lineage Leukemia

Condition: ALL, Childhood B-Cell · Acute Lymphoid Leukemia Relapse · Acute Lymphocytic Leukemia Refractory  ·  Sponsor: University Hospital Tuebingen

PhasePhase 1/Phase 2
Planned participants20
Who can joinAll sexes, 3 Years to 18 Years
Healthy volunteersNo

About this study

The objective of the trial is to evaluate the safety, clinical toxicity and in vivo immunological effects of MOR00208 in pediatric patients with acute lymphoblastic leukemia who showed newly emerging or persistent MRD after a first stem cell transplantation, received stem cell transplantation without having reached a sufficient molecular remission prior to transplant (defined as MRD ≥10E-4) irrespective of MRD after SCT or underwent a second or subsequent stem cell transplantation irrespective of MRD after SCT. Part I: to determine the recommended dose of MOR00208 in pediatric patients Part II: to evaluate the time until hematological relapse or increase of MRD

This description comes directly from the study's public registry record.

Talk to the study team

Peter Lang, Prof.  ·  0049 7071 2984744  ·  peter.lang@med.uni-tuebingen.de

Michael Abele, Dr.  ·  0049 7071 2984744  ·  michael.abele@med.uni-tuebingen.de

Always discuss trial participation with your own doctor first.

Locations (11)

Universitätsklinikum FreiburgFreiburg im Breisgau, Baden-Wurttemberg, GermanyRecruiting
University childrens HospitalTübingen, Baden-Wurttemberg, GermanyRecruiting
Klinik für Kinder- und JugendmedizinUlm, Baden-Wurttemberg, GermanyRecruiting
Klinikum Dr. von Haunersches KinderspitalMünchen, Bavaria, GermanyNot Yet Recruiting
Zentrum für Geburtshilfe, Kinder- und JugendmedizinHamburg, Free and Hanseatic City of Hamburg, GermanyRecruiting
Universitätsklinikum DüsseldorfDüsseldorf, North Rhine-Westphalia, GermanyRecruiting
Universitätsmedizin Berlin, Campus Virchow KlinikumBerlin, GermanyRecruiting
UniversitätsklinikumEssen, GermanyNot Yet Recruiting
Universitätsklinikum, Klinik für Kinder- und JugendmedizinFrankfurt, GermanyNot Yet Recruiting
Universitätsklinikum Schleswig-Holstein, Campus KielKiel, GermanyRecruiting
Universitäts-KinderklinikWürzburg, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT05366218