Condition: Kidney Cancer · Sponsor: Azienda Ospedaliero-Universitaria Careggi
Partial nephrectomy (PN) is the standard treatment for localized renal masses and should be preferred in clinical T1 (\<7 cm tumor diameter) renal tumors over radical nephrectomy (RN) whenever technically feasible. Nonetheless, indications, approaches, techniques for PN, and correct reporting of outcomes, are still a matter of great debate within the urology community. Concurrently, case-report series suggested that alternative strategies for the treatment of localized renal tumors (ablation techniques (AT), watchful waiting (WW), active surveillance (AS)) could be feasible with acceptable oncologic outcomes in particular settings of patients with localized renal tumors. In this complex clinical scenario, the role surgeon-related and environmental factors (such as surgical experience, hospital resources, countries' social background and performance of health system) are important to address the best personalized approach in patients with renal tumors. In the light of current evidence, many unsolved questions still remain and many unmet needs must be addressed. In particular, 1) the risk-benefit trade-offs between PN and RN for anatomically complex renal localized tumors; 2) the definition of evidence-based strategies to tailor the management strategy (AT vs WW vs AS vs surgery) in different subset of patients with particular clinical conditions (i.e. old, frail, comorbid patients); and 3) the definition of evidence-based recommendations to adapt surgical approach (open vs la…
This description comes directly from the study's public registry record.
Marco Carini, Prof. · 055 794 6351 · carini@unifi.it
Andrea Minervini, Prof. · 055 794 6351 · andrea.minervini@unifi.it
Always discuss trial participation with your own doctor first.
| Institute of Urology, University of Southern California. | Los Angeles, California, United States | Recruiting |
| University of California San Diego, Moores Cancer Center | San Diego, California, United States | Recruiting |
| Stanford University | Stanford, California, United States | Not Yet Recruiting |
| Loyola University Medical Center, Edward Hines VA Hospital | Chicago, Illinois, United States | Not Yet Recruiting |
| University of Pennsylvania | Philadelphia, Pennsylvania, United States | Not Yet Recruiting |
| VCU Health System | Richmond, Virginia, United States | Recruiting |
| Swedish Hospital | Seattle, Washington, United States | Not Yet Recruiting |
| Medical University of Vienna, Vienna General Hospital | Vienna, Austria | Recruiting |
| University of Bruxelles | Brussels, Belgium | Recruiting |
| University Hospitals Leuven | Leuven, Belgium | Not Yet Recruiting |
| Onze Lieve Vrouw Hospital | Leuven, Belgium | Recruiting |
| Santa Casa da Misericórdia de Fortaleza | Fortaleza, Brazil | Recruiting |
+ 25 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05363657