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Study identifier: NCT05359562 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD

Condition: OCD  ·  Sponsor: University of Pennsylvania

PhaseNA
Planned participants120
Who can joinAll sexes, 18 Years to 45 Years
Healthy volunteersNo

About this study

Studies show that hormones affect the brain's fear extinction network, which is relevant for therapy involving exposure and response prevention (EX/RP), a first-line treatment for obsessive compulsive disorder (OCD). This study will examine the effect of delivering EX/RP to women during different phases in their menstrual cycle to determine the effects of hormones on the fear extinction network and on their OCD symptoms.

This description comes directly from the study's public registry record.

Talk to the study team

Bryanna Mackey  ·  2157463344  ·  Bryanna.Mackey@Pennmedicine.upenn.edu

Sara Rose Shannon, BS, MS  ·  6467748082  ·  SaraRose.Shannon@nyspi.columbia.edu

Always discuss trial participation with your own doctor first.

Locations (2)

New York State Psychiatric InstituteNew York, New York, United StatesRecruiting
University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05359562