Condition: Fibroblast Growth Factor 23 · Anemia · CKD · Sponsor: Maimónides Biomedical Research Institute of Córdoba
Anemia is associated with cardiovascular disease. Iron deficiency is usually induced in chronic kidney disease (CKD). In clinical studies, an inverse association between serum levels of iron and fibroblast growth factor 23 (FGF23), a cardiovascular risk factor, has been demonstrated. In addition, a number of the I.V. iron presentations mostly used to treat anemia show unwanted side effects related to phosphate alterations and increased FGF23. Objectives. The General Objective of this project is to evaluate, through in vivo and in vitro studies, the cardiovascular alterations related to the anemia-induced increase in FGF23 production; as well as the identification of possible molecular targets that may be useful in its prevention and/or palliation. Specific Objectives are: 1) To determine in a population with anemia (due to iron deficiency), with and without CKD, an association between the parameters related to iron metabolism, FGF23 and markers of cardiovascular damage. 2) To evaluate in vivo, in a murine experimental model of anemia, with and without CKD, the effects of the modulation (inhibition) of triggers of iron deficiency (hepcidin) and of the increase in FGF23 (HF1α), on markers of cardiovascular damage. 3) To compare in vivo, in an experimental model of anemia with and without CKD, the effect of different I.V. iron presentations (ferrous sulphate, ferric carboxymaltose and ferric citrate) on FGF23 levels and their cardiovascular impact. 4) To evaluate in vitro, in ca…
This description comes directly from the study's public registry record.
Casimiro Valle Domínguez, MD · 34 957010000 · casimiro.valle.sspa@juntadeandalucia.es
Alejandro Martín-Malo, PhD, MD · 34 957010000 · amartinma@senefro.org
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| Hospital Universitario Reina Sofia | Córdoba, Spain | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05356325