Condition: Bacterial Infections · Sponsor: University Hospital, Toulouse
In this randomized controlled open-label trial, conducted in 7 French Pediatric and Neonatal Intensive Care Units (ICUs), investigator team hypothesize that the use of a procalcitonin (PCT)-guided algorithm to discontinue antibiotic treatment will decrease antibiotic duration in critically ill children treated for a suspected or proven bacterial infection. Two hundred and ninety-six eligible patients will be randomly assigned in two groups: either PCT-guided or standard-of-care antibiotic discontinuation, and monitored over 28 days, until the end of their hospitalization, or up to the end of antibiotic treatment for bacterial infection recurrence occurring up to 28 days after the day of randomization.
This description comes directly from the study's public registry record.
Romain AMADIEU, MD · 053-455-7495 · amadieu.r@chu-toulouse.fr
Gwennaëlle ALPHONSA · 056-777-1394 · alphonsa.g@chu-toulouse.fr
Always discuss trial participation with your own doctor first.
| CHU Amiens Picardie | Amiens, France | Active Not Recruiting |
| CHU de Bordeaux | Bordeaux, France | Active Not Recruiting |
| CHU de Clermont Ferrand | Clermont-Ferrand, France | Recruiting |
| CHU de NANTES | Nantes, France | Recruiting |
| APHP | Paris, France | Active Not Recruiting |
| CHU La Réunion | Saint-Denis, France | Recruiting |
| University Hospital of Toulouse | Toulouse, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05350813