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Study identifier: NCT05343325 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC

Condition: Head and Neck Squamous Cell Carcinoma · Neoadjuvant Treatment  ·  Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University

PhasePhase 2
Planned participants25
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

This is an open-label, single-arm, phase II clinical trial to explore the efficacy and safety of neoadjuvant low-dose radiotherapy combined with chemoimmunotherapy in resectable locally advanced head and neck squamous cell carcinoma. The eligible patients are scheduled to administered neoadjuvant low-dose radiotherapy, tislelizumab, combined with albumin-bound paclitaxel and cisplatin for two cycles. Radical resection will be performed in 3-4 weeks after two cycles of neoadjuvant therapy. The overall primary study hypothesis is that the novel neoadjuvant combination regime improves the pathological complete response (pCR) rate, with tolerable side effects.

This description comes directly from the study's public registry record.

Talk to the study team

Zhigang Liu, Dr.  ·  07562526192  ·  liuzhg9@mail.sysu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (2)

Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai, Guangdong, ChinaRecruiting
Zhigang LiuDongguan, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT05343325