Condition: Acute Myeloid Leukemia · Myelodysplastic Syndromes · Sponsor: Montefiore Medical Center
This is a Phase 1b, open-label study evaluating Venetoclax in combination with intensive induction and consolidation chemotherapy in previously untreated, adult patients with acute myeloid leukemia. In Part 1, the dose escalation phase, the safety and tolerability of the combination with Venetoclax at different doses and duration will inform the appropriate dose(s) and regimen(s) for Part 2. In Part 2, the dose expansion phase, a maximum of 28 additional patients will be randomized 1:1 to the MTD determined in Part 1 and the starting dose (assuming the MTD is not the starting dose), to further evaluate the safety and efficacy of the study drug combination.
This description comes directly from the study's public registry record.
Ioannis Mantzaris, MD · 718-920-4826 · imantzar@montefiore.org
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| Montefiore Einstein Cancer Center and Children's Hospital at Montefiore (CHAM) | The Bronx, New York, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05342584