Condition: PreDiabetes · Prediabetic State · Obesity · Sponsor: Medical University of Bialystok
The study aims to investigate the genetic basis of the response to short-term (3 months) orally administered semaglutide treatment, in terms of improving metabolic parameters, including the hormonal response to a standardized meal, and changes in body composition and liver steatosis. In the study, parameters such as fasting and 2-hour glucose during OGTT, HbA1c, body fat mass, body weight, total cholesterol, HDL and LDL, triglycerides, HOMA-IR, Matsuda Index and liver steatosis will be assessed. All the patients will undergo genome-wide genotyping. Moreover, in a subset of participants, muscle and fat biopsies will be performed, before and after the treatment, and liver, muscle and pancreas fat content will be assessed using MRI.
This description comes directly from the study's public registry record.
Lukasz Szczerbinski, MD, PhD · +48858318150 · lukasz.szczerbinski@umb.edu.pl
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| Clinical Research Centre, Medical University of Bialystok | Bialystok, Podlaskie Voivodeship, Poland | Recruiting |
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Source record: clinicaltrials.gov/study/NCT05340868