Condition: HNSCC · Oral Cavity Cancer · Oropharynx Cancer · Sponsor: University Hospital Freiburg
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.
This description comes directly from the study's public registry record.
Alexander Rühle, MD, MHBA · 004976127095200 · alexander.ruehle@uniklinik-freiburg.de
Always discuss trial participation with your own doctor first.
| Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine | Baltimore, Maryland, United States | Completed |
| Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai | New York, New York, United States | Completed |
| Department of Radiation Oncology, Case Western Reserve University | Cleveland, Ohio, United States | Completed |
| Division of Radiation Oncology, The Ohio State University Wexner | Columbus, Ohio, United States | Completed |
| Radiation Oncology Department, German Oncology Center | Limassol, Cyprus | Completed |
| Brno University Hospital | Brno, Czechia | Completed |
| Department of Radiooncology and Radiotherapy, Charité-Universitätsmedizin Berlin | Berlin, Germany | Completed |
| Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg | Erlangen, Germany | Completed |
| Department of Radiotherapy and Oncology, Goethe-University Frankfurt am Main | Frankfurt, Germany | Completed |
| University of Giessen | Giessen, Germany | Completed |
| Martin-Luther-Universität Halle-Wittenberg | Halle, Germany | Completed |
| Jena University Hospital | Jena, Germany | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05337631