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Study identifier: NCT05335928 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Abatacept in Immune Checkpoint Inhibitor Myocarditis

Condition: Myocarditis Acute · Cancer  ·  Sponsor: Massachusetts General Hospital

PhasePhase 3
Planned participants390
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.

This description comes directly from the study's public registry record.

Talk to the study team

Hannah K Gilman, MS  ·  6177261019  ·  hkgilman@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (31)

Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
University of California Los AngelesLos Angeles, California, United StatesRecruiting
MedStar Health Research Institute, Georgetown UniversityWashington D.C., District of Columbia, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
University of ChicagoChicago, Illinois, United StatesRecruiting
Franciscan HealthIndianapolis, Indiana, United StatesRecruiting
University of Kansas Medical CenterKansas City, Kansas, United StatesRecruiting
University of KentuckyLexington, Kentucky, United StatesRecruiting
Maine HealthPortland, Maine, United StatesRecruiting
Johns HopkinsBaltimore, Maryland, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting

+ 19 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05335928