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Study identifier: NCT05334888 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach

Condition: Transgender · Gut Microbiome · Immune System  ·  Sponsor: Charite University, Berlin, Germany

PhaseN/A
Planned participants200
Who can joinAll sexes, 18 Years to 50 Years
Healthy volunteersNo

About this study

The XCVD study investigates the influence of sex hormones on the composition of the gut microbiome and the possible emergence of cardiovascular risk factors. It will follow 200 healthy transgender individuals for five years during their hormone replacement therapy (HRT) and analyze them for the possible emergence of cardiovascular risk factors in relation to changes in the gut microbiome, metabolome, and immunome. We would also like to phenotype cardiovascular disease.

This description comes directly from the study's public registry record.

Talk to the study team

Sofia Forslund, Prof. Dr.  ·  +49 30 450540649  ·  sofia.forslund@mdc-berlin.de

Lajos Marko, Dr.  ·  lajos.marko@charite.de

Always discuss trial participation with your own doctor first.

Locations (1)

Experimental and Clinical Research Center, Clinical Research UnitBerlin, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT05334888