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Study identifier: NCT05334485 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pyridostigmine Efficacy and Safety for Treatment of Ileus After Colorectal Surgery

Condition: Postoperative Ileus  ·  Sponsor: Stefan Holubar MD MS FACS, FASCRS

PhasePhase 2/Phase 3
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

A double blind, placebo controlled, randomized control trial studying the safety and efficacy of pyridostigmine as a rescue therapy for postoperative ileus. Patients who undergo elective colorectal resection with or without creation of an ostomy, and subsequently develop postoperative ileus will be eligible for enrollment. Patients will be randomized to receive either pyridostigmine or placebo in addition to the current elements of standard of care. Patients will also complete the pyridostigmine bromide side effects scale (PBSES) upon enrollment and following each administration of either intervention or placebo to monitor treatment safety and evaluate for the development of side effects.

This description comes directly from the study's public registry record.

Talk to the study team

Stefan D Holubar  ·  2164447000  ·  holubas@ccf.org

Always discuss trial participation with your own doctor first.

Locations (1)

Cleveland Clinic Main CampusCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT05334485