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Study identifier: NCT05334277 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Furmonertinib Monotherapy and Combination Therapy in Advanced EGFR Mutant NSCLC With Uncleared ctDNA

Condition: Non-small Cell Lung Cancer  ·  Sponsor: Sun Yat-sen University

PhasePhase 2
Planned participants280
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

EGFR mutation positive advanced NSCLC patients with uncleared ctDNA have poor prognosis, whether they can benefit from combination therapy has not been reported. This study aims to investigate the efficacy and safety of combination therapy compared with furmonertinib monotherapy in advanced EGFR mutant NSCLC with uncleared circulating tumor cell DNA.

This description comes directly from the study's public registry record.

Talk to the study team

Zhang MD Li, 58  ·  13902282893  ·  zhangli@sysucc.org.cn

Fang Wen Feng, 46  ·  15322302066  ·  fangwf@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (26)

The First Hospital of Jilin UniversityChangchun, ChinaNot Yet Recruiting
Sichuan Provincial People's HospitalChengdu, ChinaNot Yet Recruiting
Dongguan People's HospitalDongguan, ChinaNot Yet Recruiting
Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang People's hospitalDongyang, ChinaNot Yet Recruiting
The First People's Hospital of FoshanFoshan, ChinaNot Yet Recruiting
Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou, ChinaNot Yet Recruiting
Nanfang Hospital, Southern Medical UniversityGuangzhou, ChinaNot Yet Recruiting
Sun Yat-sen University cancer centerGuangzhou, ChinaRecruiting
The First Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, ChinaNot Yet Recruiting
The First Affiliated Hospital, Zhejiang University School of MedicineHangzhou, ChinaNot Yet Recruiting
The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou, ChinaNot Yet Recruiting
Zhejiang Provincial Hospital of Chinese MedicineHangzhou, ChinaNot Yet Recruiting

+ 14 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT05334277