Condition: Triple Negative Breast Cancer · Renal Cell Cancer · High Grade Ovarian Serous Adenocarcinoma · Sponsor: Scancell Ltd
The main objectives of this study are to assess the safety, tolerability, immunological activity, and preliminary efficacy of the Modi-1 Moditope vaccine, both as monotherapy and in combination with a checkpoint inhibitor (CPI) such as pembrolizumab or nivolumab with or without Ipilimumab (where these are standard of care in a non-neoadjuvant setting), in patients with advanced triple negative breast cancer (TNBC), advanced/unresectable human papillomavirus-negative squamous cell carcinoma of the head and neck (SCCHN), high grade serous ovarian carcinoma (HGSOC), or renal cell carcinoma (RCC). Modi-1 Moditope will also be investigated in the neoadjuvant setting for patients with SCCHN undergoing curative intent surgical resection in combination with pembrolizumab versus the Modi-1 alone.
This description comes directly from the study's public registry record.
Robert Miller · +441865582690 · info@scancell.co.uk
Always discuss trial participation with your own doctor first.
| Brighton and Sussex University Hospital | Brighton, Default, United Kingdom | Active Not Recruiting |
| Velindre Cancer Centre | Cardiff, Default, United Kingdom | Recruiting |
| Edinburgh Cancer Centre (NHS Lothian) | Edinburgh, Default, United Kingdom | Recruiting |
| Royal Surrey NHS Foundation | Guildford, Default, United Kingdom | Recruiting |
| Imperial College Healthcare NHS Trust | London, Default, United Kingdom | Active Not Recruiting |
| Mount Vernon | London, Default, United Kingdom | Recruiting |
| University College London Hospital NHS Foundation Trust | London, Default, United Kingdom | Recruiting |
| Christie NHS Foundation Trust | Manchester, Default, United Kingdom | Recruiting |
| Nottingham University Hospitals Cancer Centre | Nottingham, Default, United Kingdom | Recruiting |
| Lancashire Teaching Hospitals NHS Foundation Trust | Preston, Default, United Kingdom | Recruiting |
| Sheffield Teaching Hospital NHS Foundation Trust | Sheffield, Default, United Kingdom | Recruiting |
| The Royal Marsden NHS Foundation Trust | Sutton, Default, United Kingdom | Not Yet Recruiting |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT05329532